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IL-7 suppressed PD-1 expression on CD8+ T cells. For a and b ...
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WebIn contrast to IFN-b, IL- 7 stimulation enhanced the proliferation of CD8 1 T cells (55% proliferated) and simultaneously suppressed PD-1 expression ( Figure 5 a and b). To examine the potential ... WebNov 13, 2013 · BALB/c mice vaccinated with BCG ΔureC::hly, BCG ΔureC::hly_hIL7 or BCG ΔureC::hly_hIL18 developed a more robust Th1 response than after vaccination with parental BCG. Both strains provided significantly better protection than BCG in a murine Mycobacterium tuberculosis challenge model but efficacy remained comparable to that … WebNov 13, 2013 · This vaccine shows superior protection against tuberculosis in preclinical models and is safe in humans. Here we describe two new vaccine strains which express human interleukin-7 (hIL)-7 or hIL-18 in the genetic background of BCG Δ ureC :: hly to modulate specific T cell immunity. fitbit sense 2 band size chart