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Cyp4a14基因

WebA novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem J. 1997 Aug 1;325(Pt 3):741-9. Latest. J:272457 Gilani A, et al., High-fat diet-induced obesity and insulin resistance in CYP4a14(-/-) mice is mediated by 20-HETE. Am J Physiol Regul Integr Comp Physiol. 2024 Nov 1 ... WebJul 27, 2011 · A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long-chain fatty acids ( By similarity ). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver ( PubMed: 17112342) ( By similarity ).

Cyp4a10 Polyclonal Antibody (PA3-033) - Thermo Fisher

WebBackground/aims: Cyp4a14 is a member of cytochrome P450 (Cyp450) enzyme superfamily that possesses NADPH monooxygenase activity, which catalyzes omega-hydroxylation of medium-chain fatty acids and arachidonic acid. Study suggests that down-regulation of Cyp4a14 has an anti-inflammatory response in intestine. The present study was to test … WebAngiotensin II (AngII) plays an important role in the pathogenesis of hypertension and associated renal injuries. To elucidate the molecular mechanism by which AngII induces renal damage, we found that AngII infusion significantly induced CYP4A14 expression in renal proximal tubule cells (RPTCs) with marked increases in blood pressure and … ray white real estate thornleigh https://families4ever.org

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Web目的:随着人们生活水平的提高,我国非酒精性脂肪肝的发病率越来越高.本文旨在探讨细胞色素P450ω-羟化酶CYP4A14在肝脏脂质代谢中的作用,以期为阐明非酒精性脂肪肝发生的机制提供线索.方法: (1)野生型 (WT)及CYP4A14基因敲除 (4A14KO)小鼠分为如下四组:1)WT+普通饮 … Web其中,srebp-1c是调控肝脏fa和tg合成有关基因的主要转录因子,与肝细胞内tg的过度蓄积产生脂肪毒性和胰岛素抵抗(ir)的发生密切相关。 ... 、c钾4aio、cyp4a14和cypzei mrna的表达 … Web内质网应激蛋白在Cyp4a14基因敲除小鼠肠炎模型中的表达及意义. 背景:炎症性肠病 (inflammatory bowel disease,IBD)是一种肠道的慢性非特异性炎症性疾病,其病因还未明确.内质网应激 (endoplasmic reticulum stress,ERS)参与多种疾病的发病机制,包括IBD.Cyp4a14是一种肝脏产生的与 ... ray white real estate thomastown

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Category:内质网应激蛋白在Cyp4a14基因敲除小鼠肠炎模型中的表达及意义

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Cyp4a14基因

Cyp4a14 MGI Mouse Gene Detail - MGI:1096550 - cytochrome …

WebFKBP51基因敲除 线粒体 高脂饮食 肥胖 ... 利用Real-time PCR技术,对测序结果筛选出的相关分子GCK、Cyp21al、Cyp4a10、Cyp4a14在mRNA水平的进行验证;5)电镜观察线粒体:通过电镜观察RD WT、HF WT、RDKO及HFKO四组小鼠的肝脏组织并拍照,利用软件对每组线粒体的面积进行测量,并 ... WebTo further determine the role of CYP4A14 in hepatic lipid metabolism, we fed wild-type and CYP4A14 gene knockout (cyp4a14 −/−) mice with a high-fat diet for 2 mo. Compared with HFD-fed wild-type mice, cyp4a14 −/− …

Cyp4a14基因

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WebWhether it is essential for hepatocellular proliferation and carcinogenesis is unclear due to a lack of an efficient hepatocyte-specific Myc disruption model. This study used a novel … http://fund.keyanzhiku.com/Index/info/id/ODU1MTYyMzc0YmllLXNoaS1sZS1xdS1iaWUtcmVuLWppYS1wYS1zaHUtanUtYmE%3D.html

WebMar 5, 2024 · Predicted to enable heat shock protein binding activity; heme binding activity; and monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in brain; embryo; liver; and lung. WebFeb 20, 2015 · VA Directive 6518 4 f. The VA shall identify and designate as “common” all information that is used across multiple Administrations and staff offices to serve VA …

Web百度百科是一部内容开放、自由的网络百科全书，旨在创造一个涵盖所有领域知识，服务所有互联网用户的中文知识性百科全书。在这里你可以参与词条编辑，分享贡献你的知识。 Web这个基因，cyp1a1，编码细胞色素p450酶超家族的一个成员。细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固醇、类固醇等脂类的合成。这种蛋白质定位于内质网，其表达是由一些多环芳烃（pahs）诱导的，其中一些存在于香烟烟雾中。该酶的内源底物尚不清楚，但它能将一些多环芳烃代谢为致癌

WebAug 8, 2024 · More importantly, potent expression of CYP4A was detected in liver tissues from NAFLD patients, and CYP4a14−/− mice were resistant to hepatic steatosis and fibrosis . Therefore, unravelling the roles of CYP4A in the pathogenesis of hepatic steatosis and developing methods to target CYP4A may be a valuable approach to treating human …

Webfxr还诱导fgf19表达，从而激活肝fgf受体4（fgfr4），通过jun n端激酶（jnk）介导的信号转导下调cyp7a1。另外，fxr还激活与胆汁酸葡萄糖醛酸化有关的ugt2b4基因，增加胆汁酸水 … simply tasteful soupWebMar 21, 2024 · NR1D1 (Nuclear Receptor Subfamily 1 Group D Member 1) is a Protein Coding gene. Diseases associated with NR1D1 include Hypothyroidism, Congenital, Nongoitrous, 6 and Rem Sleep Behavior … simply tasteful recipesWeb在Cyp4a14基因目的exons两侧分别插入loxP位点。该flox小鼠可与组织特异性Cre工具鼠交配,获得在特定细胞类型或组织中敲除Cyp4a14基因的小鼠模型。 ... 常见的基因工程小鼠可以分为两种命名方式，包括基因定点修饰的小鼠命名，比如：敲除、敲入、点突变等等，和 ... ray white real estate thirroulWeb脂肪酸的转运与氧化分解. lcy19712024. 关注生化领域. 60 人 赞同了该文章. 脂肪中储存的能量主要在脂肪酸中。. 脂解产生的脂肪酸与清蛋白（白蛋白）结合，生成极高密度脂蛋白，经血液循环运输到需要能量的组织。. 组 … ray white real estate timaruWeb基因调控蛋白与脂质丰度分析 作者使用QTL定位，分析HMDB中，影响蛋白质组及脂质丰度的遗传变异。 分析结果显示，蛋白顺式QTL (pQTL) 定位数据集鉴定出97819个SNP对 … ray white real estate timboonWebMar 9, 2024 · CYP4A14 may represent a useful target for the treatment of AngII-associated renal damage. this study provides a link between CYP4A14 and NAFLD. Overexpression … ray white real estate tingalpaWebThe Burn is a news and lifestyle website primarily focused on restaurants, retail, shopping centers, entertainment venues and other topics that have people buzzing in Loudoun … simply tasty ready meals