Cyclophosphamide nephrotoxic

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August undefined, 2024

WebOct 1, 2009 · The anticancer drug cyclophosphamide (CP) has nephrotoxic effects besides its urotoxicity, which both in turn limit its clinical utility. The nephrotoxicity of CP is less common compared to its ... WebCyclophosphamide (CP) is widely used as a chemotherapy against various types of cancers. However, CP is accompanied with multiple organ toxicity due to production of reactive oxygen species (ROS), induction of inflammation and consequently apoptosis. Alogliptin (Alo) is a dipeptidyl peptidase 4 (DPP …

Ethanol and cyclophosphamide induce similar nephrotoxic effects ...

WebNephrotoxicity has been observed at doses exceeding 1 g/m2 (38) and results from intratubular precipitation of MTX and its metabolites in the distal tubules, which causes an obstruc- tive tubulopathy and decreased glomerular ﬁltration (4,39). WebJan 29, 2012 · However, its therapeutic potential in cyclophosphamide (CP)-induced nephrotoxicity is not clear. So, we focused to research on the effect of PEITC against renal toxicity caused by CP and its ... la loi stasi

Cyclophosphamide-induced nephrotoxicity, genotoxicity, and …

WebIF and CP have to be activated through a metabolic step in vivo; numerous metabolites are known. While both IF and its structural isomer CP have severe urotoxic side effects, only IF is also a nephrotoxic drug, causing tubular damage resulting in Fanconi syndrome in … WebOct 30, 2012 · Cyclophosphamide, an orally active alkylating agent, is widely used to treat a variety of malignant and nonmalignant disorders. Although it has some tumour selectivity, it also possesses a wide spectrum of toxicities. The requirement of metabolic activation before cyclophosphamide exerts either its therapeutic or toxic effects is well … WebCyclophosphamide (CP) is a chemotherapeutic agent used to treat various types of cancer. Despite its nervous, hepatic, renal, and cytotoxic side effects, it is a highly … la loi stipule synonyme

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Cyclophosphamide-induced nephrotoxicity, genotoxicity, …

WebJan 29, 2012 · Nephrotoxicity Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: The protective effect of Ellagic acid January 2012 Molecular and... WebAug 19, 2024 · Increased nephrotoxicity may result from a combined effect of cyclophosphamide and, for example: Amphotericin B; Indomethacin: Acute water … assam tet lp maths syllabusWebApr 16, 2024 · One of the limiting effects of cyclophosphamide use is nephrotoxicity. Therefore, successful prevention of renal injury requires knowledge of pathogenic … assam tet

"WebNov 2, 2024 · Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of tumors. However, its association with nephrotoxicity limits its therapeutic use. Ocimum gratissimum leaf is a medicinal plant with numerous pharmacological and therapeutic efficacies, such as antioxidant, anti … " - Cyclophosphamide nephrotoxic

Cyclophosphamide nephrotoxic

Potential Protective Effects of Antioxidants against …

WebJun 1, 2024 · Cisplatin [Cis-diamminedichloroplatinum(II)] is the most nephrotoxic chemotherapeutic drug, discovered over four decades ago. Nephrotoxicity is the major … WebCyclophosphamide is a nitrogen mustard derivative. It is transformed via hepatic and intracellular enzymes to active alkylating metabolites. Cyclophosphamide is an …

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WebJul 22, 2024 · Cyclophosphamide can cause myelosuppression (leukopenia, neutropenia, thrombocytopenia and anemia), bone marrow failure, and severe immunosuppression which may lead to serious and … WebThe effect of cyclophosphamide on renal function was studied in 17 normally hydrated patients with cancer. No nephrotoxic effects were observed. High- dose …

WebOct 14, 2009 · The anticancer drug cyclophosphamide (CP) has nephrotoxic effects besides its urotoxicity, which both in turn limit its clinical utility. The nephrotoxicity of CP is less common compared to its urotoxicity, and not much importance has been given for the study of mechanism of CP-induced nephrotoxicity so far. Overproduction of reactive … WebDec 19, 2011 · Cyclophosphamide causes direct endothelial damage and haemorrhagic pericarditis or myocarditis. 5-FU was previously thought to cause acute coronary spasm, but recent evidence suggests that this drug too probably causes myocyte toxicity, which is unpredictable in nature except for an increased frequency in patients with a history of …

WebCyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several types … Weburo/nephrotoxicity. (See also Monitoring and Laboratory Tests section) Cyclophosphamide should not be used in patients with active urinary tract infections. Adequate treatment with mesna and/or strong hydration to force diuresis can markedly reduce the frequency and severity of bladder toxicity. It is important to ensure that …

WebCyclosporine is a potent and useful immunosuppressive agent used primarily in Conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function. These effects result in a variety of clinical syndromes. This review outlines the clinical …

WebApr 16, 2024 · Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful drugs with wide arrays of clinical activity. It has been in use for several … la loi taubira 2013WebNephrotoxicity is one of the adverse side effects of cyclophosphamide (CP) chemotherapy. In a recent study, we have demonstrated that oxidative stress and glutathione depletion play important roles in CP-induced renal damage. la loi taubiraWebAug 21, 2024 · Cyclophosphamide is an alkylating agent used for cancer management. 29 It is broadly used for the treatment of leukemias, lymphomas, multiple myeloma, rheumatic arthritis and prior to bone marrow transplantation. 30 Despite its wide array of clinical applications, cyclophosphamide can cause multiple organ toxicity, including … assam tet 2023WebWhen cyclophosphamide is included in combined cytotoxic regimens, it may be necessary to reduce the dose of cyclophosphamide as well as that of the other drugs. 2.3 . Preparation, Handling and Administration . Handle and dispose of cyclophosphamide in a manner consistent with other cytotoxic drugs. Caution assam tet syllabus 2021 lpWebJan 3, 2024 · RISK FACTORS FOR NEPHROTOXICITY; DRUG HANDLING IN PATIENTS ON DIALYSIS; ALKYLATING AGENTS. Bendamustine; Cyclophosphamide; Ifosfamide; Melphalan; Nitrosoureas; Temozolomide; Trabectedin; ANTIMETABOLITES. … assam tet 2023 applyWebMar 1, 2024 · Cyclophosphamide can cause myelosuppression (leukopenia, neutropenia, thrombocytopenia and anemia), bone marrow failure, and severe immunosuppression which may lead to serious and … la loi synonymeWebOct 1, 2024 · Cyclophosphamide is one of the anticancer drugs with a wide spectrum of clinical uses, such as sarcoma, lymphoma, neuroblastoma, multiple myeloma, leukemia, breast cancer, ovarian and lung cancer, etc. Its typical side effects are multiple complications, including nephrotoxicity . la loi travail