Ctgf migration

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August undefined, 2024

WebJul 12, 2014 · Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that … WebCTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN …

Adiponectin and inflammatory factors in keloid JIR

WebApr 12, 2024 · Corning 3422 inserts were used to evaluate the cell migration capacity. HLF and Hep3B cells were transfected with siUSP1 or siControl. ... The expression of CTGF, the most classical Hippo target ... WebOct 6, 2024 · Apart from inhibiting TNBC cell migration via CTGF, ATL-1 downregulated the expression of CTGF in fibroblasts and decreased the ability of breast cancer cells to transform fibroblasts into cancer-associated fibroblasts (CAFs), which in turn increased the sensitivity of TNBC cells to paclitaxel. In a mouse model, we found that ATL-1 treatments ... fixman tools south africa

CTGF - an overview ScienceDirect Topics

WebJun 1, 2002 · Connective tissue growth factor (CTGF) is a 38-kd protein, originally isolated from supernatants of human vascular endothelial cells, that promotes differentiation, proliferation, and migration of ... WebApr 13, 2024 · HIGHLIGHTS who: Samuele Negro from the Eight to ten week-old , mice were employed for laser capture microdissection (LCM) and transcriptional profiling, and for electrophysiological recordingsC BL/, mice expressing cytosolic … Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth … WebJan 27, 2024 · A novel integrin α5β1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut 55 , 856–862 (2006). can nail polish remover sanitize makeup

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CTGF facilitates cell-cell communication in chondrocytes via PI3K…

WebThe CTGF-mediated increases in κB-luciferase activities were inhibited by RGD, PD98059, U0126 or FAK, and ERK2 mutant. Taken together, our results indicated that CTGF … WebConnective Tissue Growth Factor (CTGF), also called CCN2, is a member of the CCN family. CTGF is a secreted protein produced by umbilical veins and vascular endothelial cells. CTGF possesses an Insulin-like Growth Factor (IGF)-binding domain, a thrombospondin type 1 domain, and a cysteine knot region. fixman plasterboard corner tapeWebFeb 13, 2024 · 3.3. CAP Accelerates Migration through the Activation of the YAP-CTGF-Cyr61 Axis. Quantitative real-time PCR revealed that CAP significantly stimulated YAP mRNA expression at 6 hr in GM Fbs (Figure 3(b)).CAP also tends to increase YAP at late time points in GM Fbs (18 hr) and HaCaTs (at 24 hr) (Figures 3(a) and 3(b)), and CAP … fixman store

"WebDec 12, 2024 · Angiogenesis is the main basis of the proliferative phase of wound healing, cell proliferation, migration, and differentiation. The integrity of the endothelial cell structure plays a very important role in maintaining normal blood circulation in the body. ... Connective tissue growth factor (CTGF) is a matricellular protein from the … " - Ctgf migration

Ctgf migration

WebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC activation, … WebConnective tissue growth factor (CTGF) is a signaling molecule with several roles in tissue repair and regeneration including promoting cell adhesion, cell migration, cell proliferation and angiogenesis. ... Results of the in vitro scratch assay shows that the membranes containing CTGF promoted cell migration and supported fast in vitro wound ...

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WebNov 4, 2016 · CTGF is a matricellular, multifunctional protein that can influence the activity of multiple major signaling pathways, affecting cell adhesion, migration, proliferation, and differentiation. CTGF expression increases after central nervous system (CNS) trauma in rodents, but its function after spinal cord injury has not been elucidated ( 7 – 9 ). WebIn the former study, we discovered that the expression of adiponectin was obviously decreased in keloid tissues compared with those in normal controls, furthermore, adiponectin inhibited CTGF-mediated KFs proliferation, migration and the over-accumulation of ECM. 13 But the correlation between adiponectin and inflammatory …

WebAs shown in Fig. 5, the number of Panc-1 cells that invaded through the matrigel chamber was signi fi cantly less in the group transfected with MUC1 siRNA than that observed in control groups (P b ... WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast activation protein (FAP) and the connective tissue growth factor (CTGF) can function in tumor-associated stromal cells but are practically inactive in normal adult cells. Accordingly, the …

WebJul 1, 2024 · Intriguingly, the effect of CTGF on cell migration can either be positive or negative in a cell-type-specific manner [23,24]. The differential actions of CTGF may be …

WebJan 31, 2024 · Recent studies have identified cell-derived connective tissue growth factor (CTGF) as a novel therapeutic target for the treatment of multiple human diseases, including various types of cancers [6 ...

WebMar 10, 2024 · The protein expression and mRNA levels of the profibrotic cytokines (VEGF and CTGF), migration and adhesion-associated molecules (VCAM-1 and ICAM-1), and ECM-associated molecules (MMP2 and TIMP-1) were elevated in the model group. After LN treatment, they were all significantly downregulated in the LN group (Figures 11(e)–11(k)). can nail polish remover stain clothesWebCTGF can decrease glycolysis, mitochondrial oxidative phosphorylation, ATP generation, and mtDNA copy number by increasing mtTFA protein degradation through ubiquitin proteasome pathway and in turn reduces migration and invasion of OSCC cells. Therefore, CTGF may be developed as a potential additive … fix many to many relationshipWebConnective tissue growth factor (CTGF), a cystine-knot protein of the CCN family, interacts with a variety of biological response modifiers and participates in several biological processes such as cell proliferation, migration, differentiation, and development of bone, cartilage, and angiogenesis. TGF-b upregulates CTGF expression in ... fixmapi not workingWebConnective tissue growth factor (CTGF), a cystine-knot protein of the CCN family, interacts with a variety of biological response modifiers and participates in several biological … can nail polish remover remove vinylWebJul 1, 2024 · Intriguingly, the effect of CTGF on cell migration can either be positive or negative in a cell-type-specific manner [23,24]. The differential actions of CTGF may be attributed to different interacting partners in the extracellular domain . ... Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells ... fixman duct tapeWebFeb 6, 2024 · The migration assays showed that GFs with CM from CAFs strongly enhanced GIST-T1 cell migration compared to GF only, while the effect was markedly decreased by anti-TGF-β1 blocking antibody (Fig ... fixman wasp trapWebAug 6, 2024 · Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis. ... In addition to fibrosis, CTGF has multiple functions, including cell adhesion and migration. CTGF expression is upregulated in ... can nail polish remove warts