Cisplatin apoptosis induction

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August undefined, 2024

Web1 day ago · Pomiferin suppresses apoptosis-resistant cells via induction of autophagy-dependent cell death. (A) ... Pomiferin potentiates the tumor suppression effect of cisplatin via attenuating ABCB1 activity and promoting cisplatin accumulation in tumor tissues of RM-1 drug-resistant prostate cancer bearing C57BL/6 mouse model. (A) ... WebOct 13, 2024 · Cisplatin is an inorganic platinum derivative that is widely used for chemotherapy of various solid tumours. In cancer cells, cisplatin induces DNA crosslinks and DNA adducts, triggering the...

MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin ...

WebAdditionally, to determine the effects of the combination of TAS and cisplatin on the apoptosis of NSCLC cells, flow cytometry was used to detect the apoptosis rate in A549 cells treated with cisplatin alone or combination therapy. ... Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA … WebApr 7, 2016 · Tubular cell apoptosis plays an essential pathogenic role for cisplatin-induced AKI. In this study, cell apoptosis was examined by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling (TUNEL) staining and immuno-staining for cleaved caspase 3 in kidney tissues. importance of data backup

Profiling of signaling molecules in four different human …

Web1 day ago · Pomiferin suppresses apoptosis-resistant cells via induction of autophagy-dependent cell death. (A) ... Pomiferin potentiates the tumor suppression effect of … WebOur study demonstrates that AKBA enhances the cisplatin sensitivity of NSCLC cells and that the mechanisms involve G 0 /G 1 phase arrest, apoptosis induction, and autophagy suppression via targeting p21-dependent signaling pathway. WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell... literacy tracker

Apoptosis Induction with Combined Use of Cisplatin and Fisetin in ...

Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic …

WebApr 28, 2011 · Furthermore, in agreement with a previous report, the apoptosis induced by cisplatin is dependent on the cell cycle. Indeed, cell death by apoptosis is significantly inhibited in nonproliferating cells (Fig. 5; ... Retinoid-related molecules require caspase 9 for the effective release of Smac and the rapid induction of apoptosis, ... WebAt the end of the execution phase, the apoptotic signal must come back to the nucleus to produce internucleosomal DNA degradation. Therefore, the induction of apoptosis from … importance of database administratorWebApr 2, 2024 · In our results, the group with cisplatin delivery-based electrospray (CDES) at 6 kV had an apoptosis of cancer cells approximately two times more than the group treated with cisplatin alone. importance of dashain

"WebApoptosis inducers act on several apoptosis-related proteins to promote apoptotic cell death. Depending on the agent selected and the concentrations used, apoptotic events … " - Cisplatin apoptosis induction

Cisplatin apoptosis induction

Exploring the Metabolic Differences between Cisplatin- and UV …

WebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for … WebOct 23, 2003 · Induction of p73-dependent apoptosis by cisplatin has two requirements: (1) drug-activated c-Abl tyrosine kinase and (2) cellular proficiency of the MMR complex, which, as with HMG1, links...

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WebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研一站式科研服务平台 WebIn this study, cisplatin was found to induce apoptosis in a cochlear cell line, in a dose- and duration-dependent manner. Specific caspase assays revealed an early (6 h) but transient increase in caspase 8 activity, and a delayed (12 h) increase in caspase 9 activity. The enhanced caspase 8 activity was preceded by upregulation of p53 ...

WebSep 5, 2011 · The major signaling cascade that bridges cisplatin-induced DNA lesions to apoptosis involves the sequential activation of the ataxia telangiectasia mutated (ATM)- and RAD3-related protein (ATR,... WebNext, post-target resistance mechanisms preventing induction of apoptosis by cisplatin were studied in LTTs. The mRNA expression of the apoptotic regulators BCL-xL, BCL …

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for treatment of human cancers. However, a major limitation of CDDP chemotherapy is serious drug resistance.

WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant …

WebWe previously described that blocking ALDH activity enhances the induction of apoptosis, especially in ovarian cancer stem cells treated with chemotherapeutic agents. ... In combination with DSF and cisplatin, relatively more apoptosis and necrosis were induced in cisplatin-resistant cells than in their parental cells (apoptosis and necrosis ... importance of data analysis in nursingWebNext, post-target resistance mechanisms preventing induction of apoptosis by cisplatin were studied in LTTs. The mRNA expression of the apoptotic regulators BCL-xL, BCL-xS, and BIRC5 /Survivin were elevated in all LTTs except 253J-LTT. BCL2 mRNA was slightly diminished in RT-112-LTT and 253J-LTT (Figure 4a, Figure S1d, Table S2). These … importance of data and informationWebCisplatin was found to be more cytotoxic to A172 than T98G cells in a time- and concentration-dependent manner. Cisplatin-induced cytotoxicity manifested as apoptosis, characterized by genomic DNA fragmentation, nuclear condensation and … importance of data dictionaryWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … importance of dashboards in businessWebApr 7, 2016 · Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction Metformin, one of the most common prescriptions for patients with type 2 diabetes, is reported to protect the kidney from gentamicin-induced nephrotoxicity. importance of data cleaningWebJun 1, 2007 · To investigate whether paeonol (Pae) has synergistic effects with cisplatin (CDDP) on the growth-inhibition and apoptosis-induction of human hepatoma cell lines HepG2 and SMMC-7721. Methods:... literacy traductionWebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Cell apoptosis and (G) expression of USP14, p-EGFR, EGFR, p-PI3K, PI3K, AKT, and p-AKT was measured in A549/DDP cells transfected with USP14 siRNA (siUSP14#1 or … importance of data backup essay